Our Research Engineered Microbial Cocultures to Detect and Degrade Organophosphates

Spraying pesticide in hazmat suits

Spraying pesticide in hazmat suits. Image Credit: The Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services

Principal Investigator

Ariel Furst

  • Raymond (1921) & Helen St. Laurent Career Development Professor
  • Department of Chemical Engineering

Ariel L. Furst is the Raymond (1921) & Helen St. Laurent Career Development Professor of Chemical Engineering. She received a B.S. degree in Chemistry from the University of Chicago in 2010 and a Ph.D. from CalTech in 2015. She was an A. O. Beckman Postdoctoral Fellow in the lab of Prof. Matthew Francis at UC, Berkeley developing sensors to monitor environmental pollutants. Currently, her lab combines biological, chemical, and materials engineering to solve challenges in human health and environmental sustainability. She is passionate about STEM outreach and increasing participation of underrepresented groups in engineering.

Challenge:

Can we detect and degrade organophosphate pesticides in the environment? Can we scale this technology for autonomously deployable monitoring?

Research Strategy

  • Engineer two microbial strains to act together to degrade pesticides and detect their degradation products.
  • Incorporate strains into handheld electrochemical device for on-person monitoring.
  • Develop autonomous devices based on these strains for continuous environmental monitoring.

Project description

Organophosphates, commonly used as pesticides, are extremely toxic to humans. Though some have been discontinued, many of these toxic chemicals remain widely available and continue to be used in agriculture and mosquito control, often aerosolized for distribution. Most detection strategies monitor organophosphate degradation products in blood and urine following exposure, with few examples of detection at the time of dispersal. The Furst Lab will engineer microbial cocultures for the targeted electrochemical detection and degradation of these harmful compounds. This approach provides a modular, adaptable strategy to detect and degrade harmful toxins and is expandable to additional toxic compounds.

Additional Details

Impact Areas

  • Water

Research Themes

  • Water Purification & Desalination
  • Sensors & Monitoring

Year Funded

  • 2021

Grant Type

  • Seed Grant

Status

  • Ongoing